Kaela S. Singleton, PhD
I am a developmental neuroscientist completing my postdoctoral training at Emory University. Currently, I am a NINDS DSPAN scholar, an adjunct professor at Agnes Scott College, as well as I am a co-founder and President-Elect of Black In Neuro. As a postdoc, I investigate mitochondria integrity and localization in Menkes Disease, a progressive form of childhood neurodegeneration that is triggered by dysregulation of copper.
Postdoctoral Fellow, Faundez Lab
Department of Cell Biology, Emory University
Rare Genetic Diseases, Nature’s Experiment on Human Development
Lee CE, Singleton KS, Wallin M, Faundez VF
Rare genetic diseases are the result of a continuous forward genetic screen that nature is conducting on humans. Here, we present epistemological and systems biology arguments highlighting the importance of studying these rare genetic diseases. We illustrate these principles discussing Menkes disease, an example of the discovery power afforded by rare diseases. Link to iScience
Pairing your Sox: Identification of Sox11 partner proteins and interaction domains in the developing neural plate
Singleton KS, Silva-Rodriguez P, Silva EM
Sox11, a member of the SoxC family of transcription factors, has distinct functions at different times in neural development. Here, we identify partner proteins and the domains of Xenopus Sox11 required for protein interaction and function during neurogenesis. This is the first identification of partner proteins for Xenopus Sox11 and of domains required for partner protein interactions and distinct roles in neurogenesis. Submitted to Journal of Biological Chemistry. Link to biorxiv
My research interests are driven by three key questions:
How are mature, unique neurons generated and maintained in the brain?
How do pathologic mechanisms disrupt molecular and cellular events during neuron generation and development?
Why do rare genetic diseases preponderantly affect the nervous system of children?
My graduate research focused on understanding the diverse role of Sox11 a transcription factor critical for neural development in mammalian and non-mammalian models. I identified downstream targets of Sox11 using RNA-sequencing, characterized Sox11-partner protein interactions, and established the domains responsible for Sox11 function both in vivo and in vitro.
My postdoctoral research addresses the molecular and cellular events disrupted in Menkes disease, a progressive form of childhood neurodegeneration that is triggered by dysregulation of copper. I am investigating the role of mitophagy in mitochondrial retention seen in Menkes disease by using mouse and Drosophila models.
Teaching, Mentoring & Service Philosophies
“When you get these jobs that you have been so brilliantly trained for, just remember that your real job is that if you are free, you need to free somebody else. If you have some power, then your job is to empower somebody else.”
- Toni Morrison
My teaching, mentoring and service philosophies are rooted in my research interests. I believe the formation of a successful, productive researcher is comparable to the formation of a neuron. Both processes are driven by intrinsic and extrinsic factors, which interact to create a mature and unique individual. Regarding my own maturation into a scientist, my identity as a Black Queer woman represent intrinsic factors, while my experiences at an all-women’s college and in an interdisciplinary graduate program represent extrinsic factors.
I strongly believe my career goals are enriched by the opportunity to promote diversity, equity, and inclusion as well as representation and accountability within the field. My experiences in inclusive training environments contribute to my past and present ambition. As an independent researcher, I seek to ‘pay it forward’ by continuing to generate high-quality science, participating in the education and mentorship of students, and remaining active in service to my community.