Kaela S. Singleton, PhD

(she/her/hers)

Dr. Singleton is a developmental neuroscientist completing her postdoctoral training at Emory University. She earned a Ph.D. in Neuroscience from Georgetown University, and a B.S. in Neuroscience & Classical History from Agnes Scott College. Dr. Singleton is an ENDURE Alum, DSPAN scholar, FIRST  fellow, and adjunct professor in the Biology department at Agnes Scott College. She is a co-founder and President Elect of BlackInNeuro an international  initiative to increase visibility and amplify  Black scholars in neuro related fields. As a postdoc she investigates mitochondria integrity and localization in Menkes Disease, a progressive form of childhood neurodegeneration that is triggered by dysregulation of copper.

Postdoctoral Fellow in the Faundez Lab
Department of Cell Biology, Emory University
kaela.singleton@emory.edu
Rare Genetic Diseases, Nature’s Experiment on Human Development
Lee CE, Singleton KS, Wallin M, Faundez VF

Rare genetic diseases are the result of a continuous forward genetic screen that nature is conducting on humans. Here, we present epistemological and systems biology arguments highlighting the importance of studying these rare genetic diseases. We illustrate these principles discussing Menkes disease, an example of the discovery power afforded by rare diseases. Link to iScience

Pairing your Sox: Identification of Sox11 partner proteins and interaction domains in the developing neural plate
Singleton KS, Silva-Rodriguez P, Silva EM

Sox11, a member of the SoxC family of transcription factors, has distinct functions at different times in neural development. Here, we identify partner proteins and the domains of Xenopus Sox11 required for protein interaction and function during neurogenesis. This is the first identification of partner proteins for Xenopus Sox11 and of domains required for partner protein interactions and distinct roles in neurogenesis. Submitted to Journal of Biological Chemistry. Link to biorxiv

Research &

Publications

Dr. Singleton's research interests are driven by three key questions:

  • How are mature, unique neurons generated and maintained in the brain?

  • How do pathologic mechanisms disrupt molecular and cellular events during neuron generation and development?

  • Why do rare genetic diseases preponderantly affect the nervous system of children?

Her graduate research focused on understanding the diverse role of Sox11 a transcription factor critical for neural development in mammalian and non-mammalian models. She identified downstream targets of Sox11 using RNA-sequencing, characterized Sox11-partner protein interactions, and established the domains responsible for Sox11 function both in vivo and in vitro

Her postdoctoral research addresses the molecular and cellular events disrupted in Menkes disease, a progressive form of childhood neurodegeneration that is triggered by dysregulation of copper. She is investigating the role of mitophagy in mitochondrial retention seen in Menkes disease by using mouse and Drosophila models.

Teaching, Mentoring & Service Philosophies

“When you get these jobs that you have been so brilliantly trained for, just remember that your real job is that if you are free, you need to free somebody else. If you have some power, then your job is to empower somebody else.”

- Toni Morrison

Dr. Singleton's teaching, mentoring and service philosophies are rooted in her research interests. She believes the formation of a successful, productive researcher is similar to the formation of a neuron. Both processes are driven by intrinsic and extrinsic factors, which interact to create a mature and unique individual. Regarding Dr. Singleton's maturation into a scientist, her identity as a Black Queer woman represent intrinsic factors, while her experiences at an all-women’s college and in an interdisciplinary graduate program represent extrinsic factors. 

 

Her career goals are enriched by the opportunity to promote diversity, equity, and inclusion as well as representation and accountability within the field, and her experiences in inclusive training environments contribute to her past and present ambition. As an independent researcher, she seek to ‘pay it forward’ by continuing to generate high-quality science, participating in the education and mentorship of students, and remaining active in service to the neuroscience community.

Funding

Dr. Singleton has earned numerous grants and fellowships in her scientific career. She is currently supported by: 

Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience Award

NINDS, F99NS108539

Emory's Fellowship in Research and Science Teaching Program NIGMS, 5K12GM000680-20

Image by Joey Kyber
  • Instagram
  • LinkedIn
  • Twitter

© 2020 by Kaela S. Singleton, PhD. Proudly created with Wix.com